Integrated Multi-vector-borne diseases Platform to Assess how global Change impacts Transmission using Innovative systems modeling, Novel monitoring tools, and transmission blockinG micro-organisms

Determining the geographical variation of disease vectors driven by global change is indispensable to measure current and future risks for vector-borne diseases (VBDs) transmission. Climatic and land-use changes facilitate the expansion (e.g., mosquitoes, ticks, and blackflies) or reduction (e.g., some tsetse species) of the geographic distributions of vectors. The globally poorest populations are disproportionately affected and efficient vector control is urgent. Our ability to predict disease risks and guide vector control programs requires (1) a thorough understanding of the impact of global change drivers on VBD dynamics, (2) innovative monitoringand surveillance tools to gather relevant data faster, and (3) learning about vector competence and the potential of some microorganisms to block pathogen transmission. To fill these knowledge gaps, we will (i) use remote sensing and modelling to determine vector species distributions and future geospatial dynamics from existing vector and disease data; (ii) develop and optimize innovative monitoring and surveillance trapping tools to strategically collect new data from understudied areas; (iii) develop local partnerships with rural communities through a network of local actors to identify and measure community-level barriers to vector control; (iv) develop standardized molecular pipelines to characterize vector microbiomes and identify candidate transmissionblocking microorganisms from vector samples in high risk sites; and (v) integrate these findings in an operational multi-vector dashboard to determine VBDs transmission drivers and improve management strategies. With case studies on malaria, aedes-borne diseases, sleeping sickness, onchocerciasis and CCHF in Kenya, Mozambique, and Cameroon, we propose an integrated, transdisciplinary, and multi-vector research and development approach, which will guide evidence-based public health policies and contribute to more equality in comprehensive interventions.