Targeting the interrelation between microglia, neurons, and astrocytes to counteract tau-mediated synaptic impairments and neurodegeneration in AD

Alzheimer’s disease (AD) is a common form of dementia associated with neuroinflammation and loss of neuronal synapses. To function properly, neurons require microtubules, a network of protein-based structures that facilitate the movement of substances and organelles. Central to the formation of microtubules is a protein known as tau that misfolds in AD and leads to loss of synapses. Funded by the Marie Skłodowska-Curie Actions programme, the SynapTau project aims to dissect the role of microglia – the innate immune cells in the central nervous system – in tau-mediated synaptic loss. In an experimental setting, researchers will study the protective role of specific molecules against synaptic damage, paving the way for identification of therapeutic targets for AD.